Oxydrop Nasal Drop

Indication
Oxymetazoline Hydrochlorid is indicated for the treatment of nasal congestion associated with acute or chronic rhinitis, common cold, sinusitis, upper respiratory allergies, epistaxis and hay fever. It is also used as nasal decongestant in otitis media.

Pharmacology
Oxymetazoline Hydrochloride is an imidazoline derivative sympathomimetic amine. It is a direct agonist at ?ñ-adrenoceptors but has no action on ?ý- adrenoceptors. It is used as a topical agent on the nasal mucosa, produces a rapid and long acting vasoconstriction of the arterioles, thus reducing the blood flow and diminishing swelling of the mucosa. This results in improved potency of the airway and better drainage of the nasal sinus.

Dosage
Oxymetazoline nasal spray- Adults and children (6 years of age and older): 2 or 3 sprays in each nostril twice daily for 3-5 days. Elderly: There is no need for dosage reduction in the elderly for nasal administration. Children below 6 years of age: It is not suitable for children below 6 years of age. Oxymetazoline nasal drop- Adults & children 6 years of age: 2-3 drops of 0.05% Nasal Drops in each nostril twice daily in the morning and evening. Children 2-5 years of age: 2-3 drops of 0.025% Nasal Drops in each nostril twice daily in the morning and evening

Interaction
Oxymetazoline Hydrochloride Nasal preparation should not be given to patients being treated with MAO inhibitors or within 14 days of ceasing such treatment.

Contradiction
It is contraindicated in patients with cardiovascular disease, hyperthyroidism, prostatic enlargement, angle closure glaucoma and hypersensitivity to any of its ingredients.

Side Effect
Occasionally it may cause local irritation and dryness of the mouth and throat. Temporarily discomfort such as burning, stinging, sneezing or increase in nasal discharge may occur.

Pregnancy
The safety of Oxymetazoline Hydrochloride Nasal Spray during pregnancy and lactation has not been established, but is not thought to constitute a hazard during those periods.

Precaution
Keep away from the eyes. The spray should not be used for longer than seven days without medical advice. Frequent or prolonged use may cause nasal congestion to recur or worsen.

Overdose
Overdose may give rise to local irritation and rebound congestion. Treatment need only be symptomatic.

Storage
Keep below 30?ø C temperature in a dry place, protect from light. Do not refrigerate or freeze. Keep out of the reach of children.