Normanal 500 Tablet

Indication
It is indicated in the treatment of- Acute hemorrhoidal attacks. Chronic hemorrhoidal disease. Organic and functional chronic venous insufficiency of the lower limbs with the following symptoms: heavy legs, pain, nocturnal cramps.

Pharmacology
Diosmin and Hesperidin is a phlebotonic drug and a vascular protecting agent. It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus Diosmin and Hesperidin decreases venous capacitance, venous distensibility, and venous emptying time. Diosmin and Hesperidin protects the microcirculation by fighting the microcirculation damaging process; It combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandin. Thus Diosmin and Hesperidin normalizes capillary permeability and strengthens capillary resistance. Diosmin and Hesperidin acts on the lymphatic system, It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure.

Dosage
Tablet should be taken at meal times.Acute hemorrhoidal attacks: 3 tablets twice daily for the first 4 days, then 2 tablets twice daily for three days and if required 1 tablet twice daily as maintenance dosage.Chronic hemorrhoids: 1 tablet twice daily.Chronic venous insufficiency: 1 tablet twice daily initially for seven days. Duration may be increased depending on severity.

Interaction
Proper data is not available.

Contradiction
Proper data on contraindication is not available.

Side Effect
Some cases of routine gastric disorders and neurovegetative disorders (feeling of discomfort) have been reported. In this cases discontinuation of treatment is not required.

Pregnancy
Experimental studies in animal have not demonstrated any teratogenic effects and no harmful effect have been reported in women to date. Breast feeding is not recommended during treatment

Precaution
If the hemorrhoidal symptoms do not disappear within 15 days, patient should ask doctor for advice.

Overdose

Storage
Keep below 30?øC temperature, away from light & moisture. Keep out of the reach of children.