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Cefpodoxime Suspension

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Cefpodoxime Suspension
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XepodoxÒGranules for Suspension: After reconstitution each 5 ml suspension contains Cefpodoxime Proxetil INN equivalent to Cefpodoxime 40 mg. 

INDICATIONS

Cefpodoxime is indicated for the treatment of patients infected with susceptible strains of micro-organisms which include a wide range of gram-positive & gram-negative bacteria. As it is highly stable in presence of b-lactamase enzyme, so it is more effective against gram-positive bacteria than other 3rd generation oral Cephalosporins. 

The susceptible organisms include gram-positive bacteria eg. S. aureus(including penicillinase producing strains), S. saprophyticusS. pneumoniae, S. pyogenes, S. Agalactiae, P. magnusand gram-negative bacteria eg. E. coli, K. pneumoniae, H. influenzae(including b-lactamase producer & Ampicillin resistant strains) M. catarrhalis, N. gonorrhoeae(including penicillinase producing strains), P. mirabillis, C. diversus, H. parainfluenzae, K. oxytoca, P. vulgaris, P. rettgeri.

 

Cefpodoxime is indicated in the following diseases:-

1. Lower respiratory tract infection: Acute community-acquired pneumonia, Acute bacterial exacerbation of chronic bronchitis; (2) Upper respiratory tract infection: Acute otitis media, Acute maxillary sinusitis, Pharyngitis, Tonsillitis; (3) Sexually transmitted diseases: Acute uncomplicated urethral & cervical gonorrhea, Acute ano-rectal infection in woman caused by N. gonorrhoeae; (4) Uncomplicated urinary tract infection: Cystitis, Pyuria; (5) Skin & soft tissue infections: Furuncle, Cellulitis, Subcutaneous abscess, infectious atheroma & periproctal abscess. 

DOSAGE AND ADMINISTRATION 

Cefpodoxime capsule should be administered orally with food to enhance absorption. Cefpodoxime suspension may be given without regard to food. 

The recommended doses, duration of treatment, applicable patient population is as below:

Adults (including age 13 years & older):

Type of infection

Total daily dose

Dose Frequency

Duration

Acute community-acquired pneumonia 

Acute bacterial exacerbation of chronic bronchitis

Uncomplicated gonorrhea (men/women)

Rectal gonococcal infection in women

Skin & soft tissue infection

Pharyngitis and/or tonsillitis 

Uncomplicated urinary tract infection 

Acute maxillary sinusitis

400mg

400 mg

200 mg

200 mg

800 mg

200 mg

200 mg 

400 mg 

200 mg 12 hourly

200 mg 12 hourly

200 mg12 hourly

200 mg12 hourly

400 mg 12 hourly

100 mg 12 hourly

100 mg 12 hourly

200 mg 12 hourly

14 days

10 days

Single dose 

Single dose 

(7 to 14) days

(5 to 10) days

 7 days

10 days

 

Child :

15 days -  6 months: 4 mg/kg every 12 hours

6 months - 2 years               : 40 mg every 12 hours

3 - 8 years                             : 80 mg every 12 hours 

over 9 years                          : 100 mg every 12 hours

 

Patients with renal dysfunction: For patients with severe renal impairment (creatinine clearance < 30 ml/min) the dosing intervals should be increased to 24 hourly.

Patients with liver cirrhosis: Cefpodocime proextil pharmacokinetics in cirrhotic patients are similar to those in healthy subjects. Dose adjustment is not necessary in this population. 

 

SIDE EFFECTS 

Cefpodoxime has very few side effects. The side effects include diarrhea, nausea, skin & vaginal fungal infection, abdominal pain, headache, chest pain, myalgia, dyspepsia, dizziness, vertigo, cough etc. In children incidence of fungal skin rash is more than adults. 

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Medicine FormationSuspension
Manufactured ByRangs Pharma
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