Indication
Children: In children with reduced or absence of pancreatic exocrine secretion, and Cystic fibrosis.Adults: In the conditions with deficient pancreatic exocrine function such as
Following pancreatectomy
Following total gastrectomy
Chronic pancreatitis.
Pharmacology
Pancreatin is a preparation of Pancreatin having protease, lipase and amylase enzyme activity. Pancreatin hydrolyses fats to glycerol and fatty acids, changes protein into proteoses and derived substances and converts starch into dextrins and sugars. Pancreatin is employed in the conditions where the secretion of pancreatic juice is defcient.
Dosage
1-3 tablets daily with meal or as per direction of the physician.
Interaction
Alkaline media will rupture the enteric coating. As such to prevent bursting out of the content in the stomach Pancreatin should not be used concurrently with antacid.
Contradiction
Side Effect
Pancreatin may cause buccal and perianal soreness, particularly in infants. Hypersensitivity reactions have been reported; these may be sneezing, lacrimation or skin rashes.
Pregnancy
Pregnancy category C. Not known whether Pancreatin is distributed into milk. Caution advised if Pancreatin is used.
Precaution
Pancreatin should be used with caution in patients known to be allergic to animal protein.
Overdose
Excessive dosage may produce a laxative efect. Systemic toxicity does not occur. Very high dosage may cause hyperuricemia and hyperuricos-uria.
Storage
Store in a cool and dry place. Keep out of the reach of children.