Description
MUPS is abbreviation for Multiple-Unit Pellet System. However, from pharmaceutical industry and research perspective, the term in general refers to MUPS compacted into tablets. Thus, the resulting tablets prepared by compaction of modified release coated multiparticulates or pellets are called as MUPS. It is the more recent and challenging technology that combines the advantages of both tablets and pellet filled capsules in one dosage form.MUPS ensure rapid and uniform gastric emptying and subsequently uniform drug dissolution of pellets in the gastrointestinal tract due to their small size and larger surface, uniform drug absorption is facilitated which results in consistent and controlled pharmacological action.A further reduction in inter- and intra-subject variability in drug absorption and clinical response is facilitated since the number of pellets per MUPS dosage form is much more than a conventional pellet-filled capsule and possibility of dose dumping(in stomach) and incomplete drug release is further minimized.
Indication
Omeprazole (Multiple-Unit Pellet System) is indixated in-
Duodenal and Gastric ulcers
NSAID-induced gastric and duodenal ulcers
Reflux Oesophagitis
GERD (Gastroesophageal Reflux Disease)
Eradication of H. pylori with appropriate antibiotics
Zollinger-Ellison Syndrome
Pharmacology
Omeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.Clinical advantage of omeprazole mups tablet compared to conventional modified-release omeprazole tablets and pellet-filled omeprazole capsules:
Ensures greater bioavailability
Ensures uniform emptying of micro pellets from stomach into small intestine facilitates rapid dissolution of enteric coating and drug release resulting in early Tmax and Cmax (peak time and peak plasma concentration)
Ensures lesser possibility of dose dumping
Is a combination of fast acting and sustained action
Ensures uniform drug release
Once daily dosing
Ensures lesser chance of localized irritation
Ensures better and more uniform drug absorption
Better than capsules in reducing the esophageal residence time
Minimizes fluctuation in plasma concentration of drug
Dosage
Adult:
GERD (Gastroesophageal Reflux Disease):?ÿ20 mg?ÿOnce daily for 4 weeks
Gastric ulcer:?ÿ20 mg?ÿOnce daily for 4-8 weeks; in severe cases Twice daily
Duodenal ulcer:?ÿ20 mg Once daily for 2-4 weeks; in severe cases Twice daily
NSAID-induced ulceration:?ÿ20 mg Once daily for 4-8 weeks
Reflux esophagitis:?ÿ20 mg Once daily for 4-8 weeks; in severe cases Twice daily
H. pylori eradication (Omeprazole MUPS tablet with Amoxicillin and Clarithromycin or Metronidazole):?ÿ20 mg Twice daily for 1 week
Zollinger-Ellison Syndrome:?ÿ60 mg Once daily; Usual maintenance, 20-120mg daily
Children:
Acid regurgitation in GERD (Gastroesophageal Reflux Disease):?ÿ20 mg Once daily for 2-4 week
Reflux esophagitis:?ÿ20 mg Once daily for 4-8 weeks
Interaction
Omeprazole is metabolized through CYP2C19 . When starting or stopping treatment with Omeprazole should be taken into account potential interactions with medicines which are CYP2C19 metabolized.
Contradiction
Omeprazole is contraindicated in those patients who have known hypersensitivity to any other components of the formulation.
Side Effect
Pregnancy
Not known to be harmful. Omeprazole can be used during pregnancy. Omeprazole is excreted in breast milk but is not likely to influence the child when therapeutic doses are used.
Precaution
Omeprazole tablet should be used carefully if the patient has severe liver dysfunction and severe renal impairment.
Overdose
Storage
Store in a cool (below 30?ø C) and dry place, protected from light and moisture.