Indication
Iron overload in patients with thalassaemia.
Pharmacology
Deferiprone is a chelating agent with an?ÿaffinity?ÿfor ferric ion (iron III). Deferiprone binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. Deferiprone has a lower binding affinity for other metals such as copper, aluminum and?ÿzinc?ÿthan for iron.
Dosage
Adult: 25 mg/kg tid. Doses >100 mg/kg daily are not recommended.Child: >6 yr: 25 mg/kg tid.May be taken with or without food.
Interaction
Avoid using deferiprone with aluminium-containing antacids as it can chelates trivalent metal ions.
Contradiction
Agranulocytosis, pregnancy and lactation.
Side Effect
Musculoskeletal and joint pain; GI disturbances; red-brown discoloration of urine; transient liver enzyme abnormalities; zinc deficiency; neutropenia and agranulocytosis.
Pregnancy
Pregnancy?ÿCategory D.?ÿThere is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Precaution
Hepatic and renal impairment. Neutropenia, monitor neutrophil count wkly and discontinue treatment if neutropenia develops. Limited experience in children 6-10 yr.
Overdose
Storage
Store below 30?ø C.